loading...| Preferred Name |
Prilocaine Hydrochloride |
|
| Synonyms |
Prilocaine Hydrochloride PRILOCAINE HYDROCHLORIDE 2-(Propylamino)-o-propionotoluidide Hydrochloride Citanest L-67 Xylonest |
|
| Definitions |
The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48012 |
|
| CAS_Registry |
1786-81-8 |
|
| CHEBI_ID |
CHEBI:32053 |
|
| Chemical_Formula |
C13H20N2O.HCl |
|
| code |
C48012 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. |
|
| FDA_UNII_Code |
MJW015BAPH |
|
| FULL_SYN |
Prilocaine Hydrochloride PRILOCAINE HYDROCHLORIDE 2-(Propylamino)-o-propionotoluidide Hydrochloride Citanest L-67 Xylonest |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Prilocaine Hydrochloride |
|
| Legacy Concept Name |
Prilocaine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
709375 |
|
| PDQ_Closed_Trial_Search_ID |
709375 |
|
| PDQ_Open_Trial_Search_ID |
709375 |
|
| Preferred_Name |
Prilocaine Hydrochloride |
|
| prefixIRI |
Thesaurus:C48012 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0008846 |
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| subClassOf |