loading...| Preferred Name |
Ziprasidone |
|
| Synonyms |
ZIPRASIDONE 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro- Ziprasidone Zeldox |
|
| Definitions |
A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47788 |
|
| CAS_Registry |
146939-27-7 |
|
| CHEBI_ID |
CHEBI:10119 |
|
| Chemical_Formula |
C21H21ClN4OS |
|
| code |
C47788 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. |
|
| FDA_UNII_Code |
6UKA5VEJ6X |
|
| FULL_SYN |
ZIPRASIDONE 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro- Ziprasidone Zeldox |
|
| Has_Salt_Form | ||
| label |
Ziprasidone |
|
| Legacy Concept Name |
Ziprasidone |
|
| Preferred_Name |
Ziprasidone |
|
| prefixIRI |
Thesaurus:C47788 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0380393 |
|
| subClassOf |