loading...| Preferred Name |
Trazodone Hydrochloride |
|
| Synonyms |
TRAZODONE HYDROCHLORIDE 2-(3-(4-(3-Chlorophenyl)piperazin-1-y)propyl)-1,2,4-triazolo(4,3-a)pyridine-3(2H)-one Hydrochloride 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Monohydrochloride Trazodone Hydrochloride Desyrel Trialodine |
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| Definitions |
The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47767 |
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| CAS_Registry |
25332-39-2 |
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| CHEBI_ID |
CHEBI:9655 |
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| Chemical_Formula |
C19H22ClN5O.HCl |
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| code |
C47767 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions. |
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| FDA_UNII_Code |
6E8ZO8LRNM |
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| FULL_SYN |
TRAZODONE HYDROCHLORIDE 2-(3-(4-(3-Chlorophenyl)piperazin-1-y)propyl)-1,2,4-triazolo(4,3-a)pyridine-3(2H)-one Hydrochloride 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Monohydrochloride Trazodone Hydrochloride Desyrel Trialodine |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Trazodone Hydrochloride |
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| Legacy Concept Name |
Trazodone_Hydrochloride |
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| NSC Number |
292811 |
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| Preferred_Name |
Trazodone Hydrochloride |
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| prefixIRI |
Thesaurus:C47767 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0701914 |
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| subClassOf |