loading...| Preferred Name |
Topiramate |
|
| Synonyms |
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate TOPIRAMATE Topamax Topiramate |
|
| Definitions |
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47764 |
|
| CAS_Registry |
97240-79-4 |
|
| CHEBI_ID |
CHEBI:63631 |
|
| Chemical_Formula |
C12H21NO8S |
|
| code |
C47764 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission. |
|
| FDA_UNII_Code |
0H73WJJ391 |
|
| FULL_SYN |
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate TOPIRAMATE Topamax Topiramate |
|
| label |
Topiramate |
|
| Legacy Concept Name |
Topiramate |
|
| NCI_Drug_Dictionary_ID |
670650 |
|
| PDQ_Closed_Trial_Search_ID |
670650 |
|
| PDQ_Open_Trial_Search_ID |
670650 |
|
| Preferred_Name |
Topiramate |
|
| prefixIRI |
Thesaurus:C47764 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0076829 |
|
| subClassOf |