loading...| Preferred Name |
Tiopronin |
|
| Synonyms |
Glycine, N-(2-mercapto-1-oxopropyl)- (2-Mercaptopropionyl)glycine Thiolpropionamidoacetic Acid TIOPRONIN Thiola Tiopronin |
|
| Definitions |
An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47758 |
|
| CAS_Registry |
1953-02-2 |
|
| Chemical_Formula |
C5H9NO3S |
|
| code |
C47758 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. |
|
| FDA_UNII_Code |
C5W04GO61S |
|
| FULL_SYN |
Glycine, N-(2-mercapto-1-oxopropyl)- (2-Mercaptopropionyl)glycine Thiolpropionamidoacetic Acid TIOPRONIN Thiola Tiopronin |
|
| label |
Tiopronin |
|
| Legacy Concept Name |
Tiopronin |
|
| Preferred_Name |
Tiopronin |
|
| prefixIRI |
Thesaurus:C47758 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0025405 |
|
| subClassOf |