loading...| Preferred Name |
Sulconazole Nitrate |
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| Synonyms |
SULCONAZOLE NITRATE 1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate,(+-)- Sulconazole Nitrate (+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate Exelderm |
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| Definitions |
The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47733 |
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| CAS_Registry |
61318-91-0 |
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| Chemical_Formula |
C18H15Cl3N2S.HNO3 |
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| code |
C47733 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. |
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| FDA_UNII_Code |
1T89100D5U |
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| FULL_SYN |
SULCONAZOLE NITRATE 1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate,(+-)- Sulconazole Nitrate (+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate Exelderm |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Sulconazole Nitrate |
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| Legacy Concept Name |
Sulconazole_Nitrate |
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| Preferred_Name |
Sulconazole Nitrate |
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| prefixIRI |
Thesaurus:C47733 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0144004 |
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| subClassOf |