loading...| Preferred Name |
Propafenone Hydrochloride |
|
| Synonyms |
Propafenone Hydrochloride PROPAFENONE HYDROCHLORIDE 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride Baxarytmon Rythmol |
|
| Definitions |
The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47692 |
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| CAS_Registry |
34183-22-7 |
|
| CHEBI_ID |
CHEBI:8466 |
|
| Chemical_Formula |
C21H27NO3.HCl |
|
| code |
C47692 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias. |
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| FDA_UNII_Code |
33XCH0HOCD |
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| FULL_SYN |
Propafenone Hydrochloride PROPAFENONE HYDROCHLORIDE 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride Baxarytmon Rythmol |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Propafenone Hydrochloride |
|
| Legacy Concept Name |
Propafenone_Hydrochloride |
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| NSC Number |
37855 |
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| Preferred_Name |
Propafenone Hydrochloride |
|
| prefixIRI |
Thesaurus:C47692 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700465 |
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| subClassOf |