loading...| Preferred Name |
Perindopril Erbumine |
|
| Synonyms |
PERINDOPRIL ERBUMINE Perindopril Tert-butylamine MCN-A-2833-109 Perindopril Erbumine 1H-Indole-2-carboxylic Acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-Methyl-2-propanamine(1:1) Aceon Coversyl S-9490-3 |
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| Definitions |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47666 |
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| CAS_Registry |
107133-36-8 |
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| CHEBI_ID |
CHEBI:8025 |
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| Chemical_Formula |
C19H32N2O5.C4H11N |
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| code |
C47666 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. |
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| FDA_UNII_Code |
1964X464OJ |
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| FULL_SYN |
PERINDOPRIL ERBUMINE Perindopril Tert-butylamine MCN-A-2833-109 Perindopril Erbumine 1H-Indole-2-carboxylic Acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-Methyl-2-propanamine(1:1) Aceon Coversyl S-9490-3 |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Perindopril Erbumine |
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| Legacy Concept Name |
Perindopril_Erbumine |
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| NCI_Drug_Dictionary_ID |
660818 |
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| PDQ_Closed_Trial_Search_ID |
660818 |
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| PDQ_Open_Trial_Search_ID |
660818 |
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| Preferred_Name |
Perindopril Erbumine |
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| prefixIRI |
Thesaurus:C47666 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0244718 |
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| subClassOf |