National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Orphenadrine Citrate

Synonyms

Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1)

ORPHENADRINE CITRATE

Orphenadrine Citrate

Norflex

Definitions

The citrate salt form of orphenadrine with a muscle relaxant property. Although the mechanism of action has not been fully elucidated, orphenadrine citrate appears to block cholinergic receptors, thereby interfering with the transmission of nerve impulses from the spinal cord to the muscles. It does not produce myoneural block, nor does it affect crossed extensor reflexes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47641

CAS_Registry

4682-36-4

CHEBI_ID

CHEBI:7790

Chemical_Formula

C18H23NO.C6H8O7

code

C47641

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The citrate salt form of orphenadrine with a muscle relaxant property. Although the mechanism of action has not been fully elucidated, orphenadrine citrate appears to block cholinergic receptors, thereby interfering with the transmission of nerve impulses from the spinal cord to the muscles. It does not produce myoneural block, nor does it affect crossed extensor reflexes.

FDA_UNII_Code

X0A40N8I4S

FULL_SYN

Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1)

ORPHENADRINE CITRATE

Orphenadrine Citrate

Norflex

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61868

label

Orphenadrine Citrate

Legacy Concept Name

Orphenadrine_Citrate

NCI_Drug_Dictionary_ID

787125

PDQ_Closed_Trial_Search_ID

787125

PDQ_Open_Trial_Search_ID

787125

Preferred_Name

Orphenadrine Citrate

prefixIRI

Thesaurus:C47641

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0029310

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29696

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