loading...| Preferred Name |
Nitazoxanide |
|
| Synonyms |
Salicylamide, N-(5-nitro-2-thiazolyl)-, Acetate(Ester) Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)- Nitazoxanide NITAZOXANIDE Alinia |
|
| Definitions |
A synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47637 |
|
| CAS_Registry |
55981-09-4 |
|
| Chemical_Formula |
C12H9N3O5S |
|
| code |
C47637 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum. |
|
| FDA_UNII_Code |
SOA12P041N |
|
| FULL_SYN |
Salicylamide, N-(5-nitro-2-thiazolyl)-, Acetate(Ester) Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)- Nitazoxanide NITAZOXANIDE Alinia |
|
| label |
Nitazoxanide |
|
| Legacy Concept Name |
Nitazoxanide |
|
| NCI_Drug_Dictionary_ID |
769610 |
|
| NSC Number |
697855 |
|
| PDQ_Closed_Trial_Search_ID |
769610 |
|
| PDQ_Open_Trial_Search_ID |
769610 |
|
| Preferred_Name |
Nitazoxanide |
|
| prefixIRI |
Thesaurus:C47637 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0068788 |
|
| subClassOf |