loading...| Preferred Name |
Naratriptan Hydrochloride |
|
| Synonyms |
Naratriptan Hydrochloride N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride NARATRIPTAN HYDROCHLORIDE Amerge GR 85548A |
|
| Definitions |
The hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47633 |
|
| CAS_Registry |
143388-64-1 |
|
| CHEBI_ID |
CHEBI:7479 |
|
| Chemical_Formula |
C17H25N3O2S.HCl |
|
| code |
C47633 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. |
|
| FDA_UNII_Code |
10X8X4P12Z |
|
| FULL_SYN |
Naratriptan Hydrochloride N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride NARATRIPTAN HYDROCHLORIDE Amerge GR 85548A |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Naratriptan Hydrochloride |
|
| Legacy Concept Name |
Naratriptan_Hydrochloride |
|
| Preferred_Name |
Naratriptan Hydrochloride |
|
| prefixIRI |
Thesaurus:C47633 |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0594660 |
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| subClassOf |