National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Mepivacaine Hydrochloride

Synonyms

1-Methyl-2',6'-pipecoloxylidide Monohydrochloride

MEPIVACAINE HYDROCHLORIDE

Mepivacaine Hydrochloride

(1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride

Carbocaine

Definitions

The hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. At the injection site, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47602

CAS_Registry

1722-62-9

CHEBI_ID

CHEBI:6760

Chemical_Formula

C15H22N2O.HCl

code

C47602

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. At the injection site, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation.

FDA_UNII_Code

4VFX2L7EM5

FULL_SYN

1-Methyl-2',6'-pipecoloxylidide Monohydrochloride

MEPIVACAINE HYDROCHLORIDE

Mepivacaine Hydrochloride

(1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride

Carbocaine

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61831

label

Mepivacaine Hydrochloride

Legacy Concept Name

Mepivacaine_Hydrochloride

NCI_Drug_Dictionary_ID

751573

PDQ_Closed_Trial_Search_ID

751573

PDQ_Open_Trial_Search_ID

751573

Preferred_Name

Mepivacaine Hydrochloride

prefixIRI

Thesaurus:C47602

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0700542

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C245

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