loading...| Preferred Name |
Memantine Hydrochloride |
|
| Synonyms |
memantine hydrochloride Memantine Hydrochloride 1-amino-3,5-dimethyladamantane Hydrochloride MEMANTINE HYDROCHLORIDE Ebixia Namenda |
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| Definitions |
The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47601 |
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| ALT_DEFINITION |
A drug used to treat dementia caused by Alzheimer disease. It is also being studied in the treatment of side effects from whole-brain radiation therapy for cancer and other conditions. Memantine hydrochloride blocks the uptake of calcium by certain brain cells and decreases their activity. It is a type of N-methyl-D-asparatate (NMDA) receptor antagonist. |
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| CAS_Registry |
41100-52-1 |
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| CHEBI_ID |
CHEBI:64323 |
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| Chemical_Formula |
C12H21N.HCl |
|
| code |
C47601 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. |
|
| Display_Name |
Memantine Hydrochloride |
|
| FDA_UNII_Code |
JY0WD0UA60 |
|
| FULL_SYN |
memantine hydrochloride Memantine Hydrochloride 1-amino-3,5-dimethyladamantane Hydrochloride MEMANTINE HYDROCHLORIDE Ebixia Namenda |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Memantine Hydrochloride |
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| Legacy Concept Name |
Memantine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
579596 |
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| NSC Number |
102290 |
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| PDQ_Closed_Trial_Search_ID |
579596 |
|
| PDQ_Open_Trial_Search_ID |
579596 |
|
| Preferred_Name |
Memantine Hydrochloride |
|
| prefixIRI |
Thesaurus:C47601 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0771988 |
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| subClassOf |