loading...| Preferred Name |
Frovatriptan Succinate |
|
| Synonyms |
1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-,(3R)-, Butanedioate(1:1) FROVATRIPTAN SUCCINATE Frovatriptan Succinate Frova |
|
| Definitions |
The succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity. Frovatriptan succinate binds selectively and with high affinity to 5-HT 1B and presynaptic 5-HT 1D receptors in the extracerebral and intracranial arteries. This leads to an inhibition of serotonin activity and results in vasoconstriction of the painfully dilated blood vessels during migraine attack. Frovatriptan succinate is indicated for the acute treatment of migraine. (NCI05) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47544 |
|
| CAS_Registry |
158930-17-7 |
|
| Chemical_Formula |
C14H17N3O.C4H6O4.H2O |
|
| code |
C47544 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity. Frovatriptan succinate binds selectively and with high affinity to 5-HT 1B and presynaptic 5-HT 1D receptors in the extracerebral and intracranial arteries. This leads to an inhibition of serotonin activity and results in vasoconstriction of the painfully dilated blood vessels during migraine attack. Frovatriptan succinate is indicated for the acute treatment of migraine. (NCI05) |
|
| FDA_UNII_Code |
D28J6W18HY |
|
| FULL_SYN |
1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-,(3R)-, Butanedioate(1:1) FROVATRIPTAN SUCCINATE Frovatriptan Succinate Frova |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Frovatriptan Succinate |
|
| Legacy Concept Name |
Frovatriptan_Succinate |
|
| Preferred_Name |
Frovatriptan Succinate |
|
| prefixIRI |
Thesaurus:C47544 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1099777 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/SNOMEDCT/370214004 | SNOMEDCT | LOOM | |
| http://purl.bioontology.org/ontology/RXNORM/322249 | RXNORM | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C47544 | BERO | LOOM |