Preferred Name |
Etomidate |
|
Synonyms |
1H-Imidazole-5-Carboxylic Acid, 1-((1R)-1-phenylethyl)-, Ethyl Ester R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate Amidate ETOMIDATE Etomidate |
|
Definitions |
An imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47527 |
|
CAS_Registry |
33125-97-2 |
|
CHEBI_ID |
CHEBI:4910 |
|
Chemical_Formula |
C14H16N2O2 |
|
code |
C47527 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159412 |
|
Contributing_Source |
CPTAC FDA |
|
DEFINITION |
An imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization. |
|
FDA_UNII_Code |
Z22628B598 |
|
FULL_SYN |
1H-Imidazole-5-Carboxylic Acid, 1-((1R)-1-phenylethyl)-, Ethyl Ester R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate Amidate ETOMIDATE Etomidate |
|
label |
Etomidate |
|
Legacy Concept Name |
Etomidate |
|
Preferred_Name |
Etomidate |
|
prefixIRI |
Thesaurus:C47527 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0015131 |
|
subClassOf |