loading...| Preferred Name |
Dihydroergotamine Mesylate |
|
| Synonyms |
Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'alpha)-, monomethanesulfonate(salt) 9,10-Dihydroergotamine Mesylate Dihydroergotamine Mesylate DIHYDROERGOTAMINE MESYLATE Migranal |
|
| Definitions |
An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47491 |
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| CAS_Registry |
6190-39-2 |
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| CHEBI_ID |
CHEBI:59756 |
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| Chemical_Formula |
C33H37N5O5.CH4O3S |
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| code |
C47491 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. |
|
| FDA_UNII_Code |
81AXN7R2QT |
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| FULL_SYN |
Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'alpha)-, monomethanesulfonate(salt) 9,10-Dihydroergotamine Mesylate Dihydroergotamine Mesylate DIHYDROERGOTAMINE MESYLATE Migranal |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Dihydroergotamine Mesylate |
|
| Legacy Concept Name |
Dihydroergotamine_Mesylate |
|
| Preferred_Name |
Dihydroergotamine Mesylate |
|
| prefixIRI |
Thesaurus:C47491 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700532 |
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| subClassOf |