loading...| Preferred Name |
Bivalirudin |
|
| Synonyms |
Bivalirudin L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl- BIVALIRUDIN Hirulog |
|
| Definitions |
A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47415 |
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| ALT_DEFINITION |
Bivalirudin is a semisynthetic derivative of hirudin and is a highly specific inhibitor of thrombin. |
|
| CAS_Registry |
128270-60-0 |
|
| CHEBI_ID |
CHEBI:59173 |
|
| Chemical_Formula |
C98H138N24O33 |
|
| code |
C47415 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 |
|
| Contributing_Source |
ACC/AHA FDA HemOnc |
|
| DEFINITION |
A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina. |
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| FDA_UNII_Code |
TN9BEX005G |
|
| FULL_SYN |
Bivalirudin L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl- BIVALIRUDIN Hirulog |
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| Has_Salt_Form | ||
| label |
Bivalirudin |
|
| Legacy Concept Name |
Bivalirudin |
|
| Preferred_Name |
Bivalirudin |
|
| prefixIRI |
Thesaurus:C47415 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0168273 |
|
| subClassOf |