loading...| Preferred Name |
Atomoxetine Hydrochloride |
|
| Synonyms |
Atomoxetine Hydrochloride ATOMOXETINE HYDROCHLORIDE (-)-N-methyl-gamma(2-methylphenoxy)benzenepropamine Hydrochloride (-)-N -Methyl-3-phenyl-3-(o-tolyloxy)-propylamine Hydrochloride Strattera Tomoxetine |
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| Definitions |
The hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47405 |
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| CAS_Registry |
82248-59-7 |
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| CHEBI_ID |
CHEBI:331697 |
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| Chemical_Formula |
C17H21NO.ClH |
|
| code |
C47405 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels. |
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| FDA_UNII_Code |
57WVB6I2W0 |
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| FULL_SYN |
Atomoxetine Hydrochloride ATOMOXETINE HYDROCHLORIDE (-)-N-methyl-gamma(2-methylphenoxy)benzenepropamine Hydrochloride (-)-N -Methyl-3-phenyl-3-(o-tolyloxy)-propylamine Hydrochloride Strattera Tomoxetine |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Atomoxetine Hydrochloride |
|
| Legacy Concept Name |
Atomoxetine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
475797 |
|
| PDQ_Closed_Trial_Search_ID |
475797 |
|
| PDQ_Open_Trial_Search_ID |
475797 |
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| Preferred_Name |
Atomoxetine Hydrochloride |
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| prefixIRI |
Thesaurus:C47405 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1170741 |
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| subClassOf |