loading...| Preferred Name |
Enalapril Maleate |
|
| Synonyms |
Enalapril Maleate ENALAPRIL MALEATE Enacard Renitec Vasotec |
|
| Definitions |
The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C468 |
|
| CAS_Registry |
76095-16-4 |
|
| CHEBI_ID |
CHEBI:4785 |
|
| Chemical_Formula |
C20H28N2O5.C4H4O4 |
|
| code |
C468 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| Display_Name |
Enalapril Maleate |
|
| FDA_UNII_Code |
9O25354EPJ |
|
| FULL_SYN |
Enalapril Maleate ENALAPRIL MALEATE Enacard Renitec Vasotec |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Enalapril Maleate |
|
| Legacy Concept Name |
Enalapril |
|
| NCI_Drug_Dictionary_ID |
42544 |
|
| PDQ_Closed_Trial_Search_ID |
42544 |
|
| PDQ_Open_Trial_Search_ID |
42544 |
|
| Preferred_Name |
Enalapril Maleate |
|
| prefixIRI |
Thesaurus:C468 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0700452 |
|
| subClassOf |