loading...| Preferred Name |
Phenoxybenzamine Hydrochloride |
|
| Synonyms |
Dibenzyline Phenoxybenzamine Hydrochloride PHENOXYBENZAMINE HYDROCHLORIDE N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride |
|
| Definitions |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C44435 |
|
| CAS_Registry |
63-92-3 |
|
| Chemical_Formula |
C18H22ClNO.HCl |
|
| code |
C44435 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
|
| FDA_UNII_Code |
X1IEG24OHL |
|
| FULL_SYN |
Dibenzyline Phenoxybenzamine Hydrochloride PHENOXYBENZAMINE HYDROCHLORIDE N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Phenoxybenzamine Hydrochloride |
|
| Legacy Concept Name |
Phenoxybenzamine |
|
| NCI_Drug_Dictionary_ID |
703206 |
|
| NSC Number |
37448 |
|
| PDQ_Closed_Trial_Search_ID |
703206 |
|
| PDQ_Open_Trial_Search_ID |
703206 |
|
| Preferred_Name |
Phenoxybenzamine Hydrochloride |
|
| prefixIRI |
Thesaurus:C44435 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0701367 |
|
| subClassOf |