loading...| Preferred Name |
Phentolamine Mesylate |
|
| Synonyms |
PHENTOLAMINE MESYLATE Phentolamine Mesylate 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Monomethanesulfonate Regitine |
|
| Definitions |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38691 |
|
| Accepted_Therapeutic_Use_For |
Dermal necrosis; Hypertensive-associated episodes with pheochromocytoma, prevention or control |
|
| CAS_Registry |
65-28-1 |
|
| Chemical_Formula |
C17H19N3O.CH4O3S |
|
| code |
C38691 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
| Display_Name |
Phentolamine Mesylate |
|
| FDA_UNII_Code |
Y7543E5K9T |
|
| FULL_SYN |
PHENTOLAMINE MESYLATE Phentolamine Mesylate 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Monomethanesulfonate Regitine |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Phentolamine Mesylate |
|
| Legacy Concept Name |
Phentolamine |
|
| NCI_Drug_Dictionary_ID |
360460 |
|
| PDQ_Closed_Trial_Search_ID |
360460 |
|
| PDQ_Open_Trial_Search_ID |
360460 |
|
| Preferred_Name |
Phentolamine Mesylate |
|
| prefixIRI |
Thesaurus:C38691 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0733398 |
|
| subClassOf |