loading...| Preferred Name |
Diphenhydramine Hydrochloride |
|
| Synonyms |
Diphenhydramine Hydrochloride Diphenhydramine.HCl SK-Diphenhydramine DIPHENHYDRAMINE HYDROCHLORIDE Diphenhydramine hydrochloride Benadryl Bendylate Eldadryl |
|
| Definitions |
The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C300 |
|
| CAS_Registry |
147-24-0 |
|
| CHEBI_ID |
CHEBI:4637 |
|
| Chemical_Formula |
C17H21NO.HCl |
|
| code |
C300 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. |
|
| Display_Name |
Diphenhydramine Hydrochloride |
|
| FDA_UNII_Code |
TC2D6JAD40 |
|
| FULL_SYN |
Diphenhydramine Hydrochloride Diphenhydramine.HCl SK-Diphenhydramine DIPHENHYDRAMINE HYDROCHLORIDE Diphenhydramine hydrochloride Benadryl Bendylate Eldadryl |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Diphenhydramine Hydrochloride |
|
| Legacy Concept Name |
Diphenhydramine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
39163 |
|
| NSC Number |
33299 |
|
| PDQ_Closed_Trial_Search_ID |
39163 |
|
| PDQ_Open_Trial_Search_ID |
39163 |
|
| Preferred_Name |
Diphenhydramine Hydrochloride |
|
| prefixIRI |
Thesaurus:C300 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0004963 |
|
| subClassOf |