Preferred Name |
Anti-MUC-1 Monoclonal Antibody |
|
Synonyms |
Anti-MUC-1 Monoclonal Antibody Anti-MUC-1 |
|
Definitions |
A monoclonal antibody recognizing human mucin, a cell surface antigen encoded by the MUC-1 gene. In normal tissue, mucin exists as heavily glycosylated form, while tumor-associated mucin molecules are hypo-glycosylated. Hypo-glycosylation exposes the normally cryptic tandem peptide repeats in cancer-associated mucin, thereby allows antigen-antibody interaction with MUC-1 antibody. As a result, the MUC-1 antibody inhibits the initiation of the immunosuppressive cascade triggered by mucin, including production and secretion of prostaglandin E2 (PGE2), followed by VEGF induction and suppression of natural killer cell, lymphokine-activated killer cell and cytotoxic T cell activity. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29983 |
|
code |
C29983 |
|
DEFINITION |
A monoclonal antibody recognizing human mucin, a cell surface antigen encoded by the MUC-1 gene. In normal tissue, mucin exists as heavily glycosylated form, while tumor-associated mucin molecules are hypo-glycosylated. Hypo-glycosylation exposes the normally cryptic tandem peptide repeats in cancer-associated mucin, thereby allows antigen-antibody interaction with MUC-1 antibody. As a result, the MUC-1 antibody inhibits the initiation of the immunosuppressive cascade triggered by mucin, including production and secretion of prostaglandin E2 (PGE2), followed by VEGF induction and suppression of natural killer cell, lymphokine-activated killer cell and cytotoxic T cell activity. |
|
FULL_SYN |
Anti-MUC-1 Monoclonal Antibody Anti-MUC-1 |
|
label |
Anti-MUC-1 Monoclonal Antibody |
|
Legacy Concept Name |
Anti-MUC-1_Monoclonal_Antibody |
|
Preferred_Name |
Anti-MUC-1 Monoclonal Antibody |
|
prefixIRI |
Thesaurus:C29983 |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Immunologic Factor |
|
UMLS_CUI |
C1510931 |
|
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/NCIT_C29983 | BERO | LOOM |