loading...| Preferred Name |
Pyrazinamide |
|
| Synonyms |
PYRAZINAMIDE Pyrazinamide |
|
| Definitions |
A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29395 |
|
| CAS_Registry |
98-96-4 |
|
| CHEBI_ID |
CHEBI:45285 |
|
| Chemical_Formula |
C5H5N3O |
|
| code |
C29395 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04) |
|
| FDA_UNII_Code |
2KNI5N06TI |
|
| FULL_SYN |
PYRAZINAMIDE Pyrazinamide |
|
| Is_Value_For_GDC_Property | ||
| label |
Pyrazinamide |
|
| Legacy Concept Name |
Pyrazinamide |
|
| Maps_To |
Pyrazinamide |
|
| NCI_Drug_Dictionary_ID |
701809 |
|
| NSC Number |
14911 |
|
| PDQ_Closed_Trial_Search_ID |
701809 |
|
| PDQ_Open_Trial_Search_ID |
701809 |
|
| Preferred_Name |
Pyrazinamide |
|
| prefixIRI |
Thesaurus:C29395 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0034239 |
|
| subClassOf |