loading...| Preferred Name |
Cyproheptadine Hydrochloride |
|
| Synonyms |
Cyproheptadine Hydrochloride 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride Sesquihydrate CYPROHEPTADINE HYDROCHLORIDE Periactin |
|
| Definitions |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28949 |
|
| Accepted_Therapeutic_Use_For |
Hypersensitivity reactions |
|
| CAS_Registry |
41354-29-4 |
|
| CHEBI_ID |
CHEBI:650917 CHEBI:59695 |
|
| Chemical_Formula |
2C21H21N.2HCl.3H2O |
|
| code |
C28949 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04) |
|
| Display_Name |
Cyproheptadine Hydrochloride |
|
| FDA_UNII_Code |
NJ82J0F8QC |
|
| FULL_SYN |
Cyproheptadine Hydrochloride 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride Sesquihydrate CYPROHEPTADINE HYDROCHLORIDE Periactin |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Cyproheptadine Hydrochloride |
|
| Legacy Concept Name |
Cyproheptadine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
315774 |
|
| NSC Number |
169911 |
|
| PDQ_Closed_Trial_Search_ID |
315774 |
|
| PDQ_Open_Trial_Search_ID |
315774 |
|
| Preferred_Name |
Cyproheptadine Hydrochloride |
|
| prefixIRI |
Thesaurus:C28949 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0354872 |
|
| subClassOf |