loading...| Preferred Name |
Candesartan Cilexetil |
|
| Synonyms |
Candesartan Cilexetil CANDESARTAN CILEXETIL Atacand Blopress |
|
| Definitions |
A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28903 |
|
| CAS_Registry |
145040-37-5 |
|
| Chemical_Formula |
C33H34N6O6 |
|
| code |
C28903 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. |
|
| FDA_UNII_Code |
R85M2X0D68 |
|
| FULL_SYN |
Candesartan Cilexetil CANDESARTAN CILEXETIL Atacand Blopress |
|
| label |
Candesartan Cilexetil |
|
| Legacy Concept Name |
Candesartan_Cilexetil |
|
| NCI_Drug_Dictionary_ID |
546971 |
|
| PDQ_Closed_Trial_Search_ID |
546971 |
|
| PDQ_Open_Trial_Search_ID |
546971 |
|
| Preferred_Name |
Candesartan Cilexetil |
|
| prefixIRI |
Thesaurus:C28903 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0527379 |
|
| subClassOf |