loading...| Preferred Name | Alprostadil | |
| Synonyms |
ALPROSTADIL alprostadil Muse (intraurethral alprostadil suppository) (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid Alprostadil Prostaglandin E1 prostaglandin E1 Caverject MUSE PGE1 |
|
| Definitions |
The naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28816 |
|
| Accepted_Therapeutic_Use_For |
Erectile dysfunction; Patent ductus arteriosus |
|
| ALT_DEFINITION |
A drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator. |
|
| CAS_Registry |
745-65-3 |
|
| CHEBI_ID |
CHEBI:15544 |
|
| Chemical_Formula |
C20H34O5 |
|
| code |
C28816 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. |
|
| Display_Name |
Alprostadil |
|
| FDA_UNII_Code |
F5TD010360 |
|
| FULL_SYN |
ALPROSTADIL alprostadil Muse (intraurethral alprostadil suppository) (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid Alprostadil Prostaglandin E1 prostaglandin E1 Caverject MUSE PGE1 |
|
| label |
Alprostadil |
|
| Legacy Concept Name |
Alprostadil |
|
| NCI_Drug_Dictionary_ID |
360459 |
|
| NSC Number |
165559 |
|
| PDQ_Closed_Trial_Search_ID |
360459 |
|
| PDQ_Open_Trial_Search_ID |
360459 |
|
| Preferred_Name |
Alprostadil |
|
| prefixIRI |
Thesaurus:C28816 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0002335 |
|
| subClassOf |