loading...| Preferred Name |
Azacitidine |
|
| Synonyms |
5-Aza-cytidine 5-Azacitidine Azacitidine Azacytidine azacitidine 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one Ladakamycin AZACITIDINE Azacytidine, 5- 5-Azacytidine 5 AZC 5-AC 5-AZC Mylosar U-18496 Vidaza |
|
| Definitions |
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C288 |
|
| Accepted_Therapeutic_Use_For |
Myelodysplastic Syndrome; acute myeloid leukemia |
|
| ALT_DEFINITION |
A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
320-67-2 |
|
| CHEBI_ID |
CHEBI:2038 |
|
| Chemical_Formula |
C8H12N4O5 |
|
| code |
C288 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04) |
|
| Display_Name |
Azacitidine |
|
| FDA_UNII_Code |
M801H13NRU |
|
| FULL_SYN |
5-Aza-cytidine 5-Azacitidine Azacitidine Azacytidine azacitidine 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one Ladakamycin AZACITIDINE Azacytidine, 5- 5-Azacytidine 5 AZC 5-AC 5-AZC Mylosar U-18496 Vidaza |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Azacitidine |
|
| Legacy Concept Name |
Azacitidine |
|
| Maps_To |
Azacitidine |
|
| NCI_Drug_Dictionary_ID |
39153 |
|
| NSC Number |
102816 |
|
| PDQ_Closed_Trial_Search_ID |
39153 |
|
| PDQ_Open_Trial_Search_ID |
39153 |
|
| Preferred_Name |
Azacitidine |
|
| prefixIRI |
Thesaurus:C288 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0004475 |
|
| subClassOf |