National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

DNA Binding Agent
Synonyms

DNA Binding Agent
Definitions

DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2842
code

C2842
DEFINITION

DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking.
FULL_SYN

DNA Binding Agent
label

DNA Binding Agent
Legacy Concept Name

DNA_Binding_Agent
Preferred_Name

DNA Binding Agent
prefixIRI

Thesaurus:C2842
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C1511661
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186664
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