loading...| Preferred Name |
Arginine Butyrate |
|
| Synonyms |
L-Arginine, Butanoate (3:4) ARGININE BUTYRATE Short Chain Fatty Acid HQK-1004 SCFA HQK-1004 Arginine Butyrate arginine butyrate HQK-1004 VX-105 |
|
| Definitions |
A compound composed of the short chain fatty acid (SCFA) butyrate combined with the amino acid arginine, with potential Epstein-Barr virus thymidine kinase gene (EBV-TK)-inducing activity. Upon administration, arginine butyrate induces the expression of thymidine kinase (TK). This activates a co-administered antiviral, such as ganciclovir, and results in the destruction of EBV-infected cancer cells. In addition, butyrate inhibits histone deacetylase (HDAC), which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2570 |
|
| ALT_DEFINITION |
A substance that is being studied as a treatment for cancer. |
|
| CAS_Registry |
80407-72-3 |
|
| Chemical_Formula |
3C6H14N4O2.4C4H8O2 |
|
| code |
C2570 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A compound composed of the short chain fatty acid (SCFA) butyrate combined with the amino acid arginine, with potential Epstein-Barr virus thymidine kinase gene (EBV-TK)-inducing activity. Upon administration, arginine butyrate induces the expression of thymidine kinase (TK). This activates a co-administered antiviral, such as ganciclovir, and results in the destruction of EBV-infected cancer cells. In addition, butyrate inhibits histone deacetylase (HDAC), which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. |
|
| Display_Name |
Arginine Butyrate |
|
| FDA_UNII_Code |
IK8S1P79MU |
|
| FULL_SYN |
L-Arginine, Butanoate (3:4) ARGININE BUTYRATE Short Chain Fatty Acid HQK-1004 SCFA HQK-1004 Arginine Butyrate arginine butyrate HQK-1004 VX-105 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Arginine Butyrate |
|
| Legacy Concept Name |
Arginine_Butyrate |
|
| Maps_To |
Short Chain Fatty Acid HQK-1004 Arginine Butyrate |
|
| NCI_Drug_Dictionary_ID |
42492 |
|
| PDQ_Closed_Trial_Search_ID |
42492 |
|
| PDQ_Open_Trial_Search_ID |
42492 |
|
| Preferred_Name |
Arginine Butyrate |
|
| prefixIRI |
Thesaurus:C2570 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0052329 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000042492 | PDQ | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C2570 | BERO | LOOM | |
| http://phenomebrowser.net/ontologies/mesh/mesh.owl#C033018 | RH-MESH | LOOM | |
| http://purl.bioontology.org/ontology/MESH/C033018 | MESH | LOOM |