loading...| Preferred Name |
Allopurinol |
|
| Synonyms |
ALLOPURINOL allopurinol 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one 4-Hydroxypyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidin-4-ol Allopurinol 4'-HPP Lopurin Sigapurol Zurinol |
|
| Definitions |
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C224 |
|
| ALT_DEFINITION |
A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments. |
|
| CAS_Registry |
315-30-0 |
|
| CHEBI_ID |
CHEBI:40279 |
|
| Chemical_Formula |
C5H4N4O |
|
| code |
C224 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04) |
|
| Display_Name |
Allopurinol |
|
| FDA_UNII_Code |
63CZ7GJN5I |
|
| FULL_SYN |
ALLOPURINOL allopurinol 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one 4-Hydroxypyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidin-4-ol Allopurinol 4'-HPP Lopurin Sigapurol Zurinol |
|
| Has_Salt_Form | ||
| Has_Target | ||
| label |
Allopurinol |
|
| Legacy Concept Name |
Allopurinol |
|
| NCI_Drug_Dictionary_ID |
38452 |
|
| NSC Number |
101655 1390 |
|
| PDQ_Closed_Trial_Search_ID |
38452 |
|
| PDQ_Open_Trial_Search_ID |
38452 |
|
| Preferred_Name |
Allopurinol |
|
| prefixIRI |
Thesaurus:C224 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0002144 |
|
| subClassOf |