loading...| Preferred Name |
Imidazole Mustard |
|
| Synonyms |
5-(3,3-BIS(2-CHLORETHYL)-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE TIC Mustard Imidazole Mustard 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide TIC mustard 5-[3,3-Bis(2-Chloroethyl)-1-Triazeno]Imidazole-4-Carboxamide Imidazole mustard BIC |
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| Definitions |
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2216 |
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| CAS_Registry |
5034-77-5 |
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| code |
C2216 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04) |
|
| FDA_UNII_Code |
OY338X4M2P |
|
| FULL_SYN |
5-(3,3-BIS(2-CHLORETHYL)-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE TIC Mustard Imidazole Mustard 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide TIC mustard 5-[3,3-Bis(2-Chloroethyl)-1-Triazeno]Imidazole-4-Carboxamide Imidazole mustard BIC |
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| Is_Value_For_GDC_Property | ||
| label |
Imidazole Mustard |
|
| Legacy Concept Name |
Imidazole_Mustard |
|
| Maps_To |
Imidazole Mustard |
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| NCI_Drug_Dictionary_ID |
39483 |
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| NSC Number |
82196 |
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| PDQ_Closed_Trial_Search_ID |
39483 |
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| PDQ_Open_Trial_Search_ID |
39483 |
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| Preferred_Name |
Imidazole Mustard |
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| prefixIRI |
Thesaurus:C2216 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0063382 |
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| subClassOf |