National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cyclin-Dependent Kinase Inhibitor
Synonyms

CDK Inhibitor

Cyclin-Dependent Kinase Inhibitor

CDKI
Definitions

Any substance that inhibits cyclin-dependent kinase (CDK), an enzyme that catalyzes the addition of a phosphate group to a protein in the cell cycle regulation pathway. Inhibition of cyclin-dependent kinase results in cell cycle arrest and apoptosis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2185
code

C2185
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977
Contributing_Source

CTRP
DEFINITION

Any substance that inhibits cyclin-dependent kinase (CDK), an enzyme that catalyzes the addition of a phosphate group to a protein in the cell cycle regulation pathway. Inhibition of cyclin-dependent kinase results in cell cycle arrest and apoptosis.
Display_Name

Cyclin-Dependent Kinase Inhibitor
FULL_SYN

CDK Inhibitor

Cyclin-Dependent Kinase Inhibitor

CDKI
label

Cyclin-Dependent Kinase Inhibitor
Legacy Concept Name

Cyclin-Dependent_Kinase_Inhibitor_Drug
Preferred_Name

Cyclin-Dependent Kinase Inhibitor
prefixIRI

Thesaurus:C2185
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C1511576
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61074

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163758

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129825
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