National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Thrombopoietin

Synonyms

Megakaryocyte Colony-Stimulating Factor

Megakaryocyte Stimulating Factor

C-MPL Ligand

Megakaryocyte Growth and Development Factor

Megakaryocyte Colony Stimulating Factor

Thrombopoietin

thrombopoietin

Prepro-Thrombopoietin

Myeloproliferative Leukemia Virus Oncogene Ligand

MGDF

ML

MPL Ligand

THPO

TPO

TSF

Definitions

Thrombopoietin (353 aa, ~38 kDa) is encoded by the human THPO gene. This protein is involved in both megakaryocyte differentiation and platelet activation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20441

ALT_DEFINITION

A substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is called recombinant human TPO and rHu TPO. TPO is being studied as a way to increase the number of platelets in cancer patients receiving chemotherapy.

code

C20441

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

Thrombopoietin (353 aa, ~38 kDa) is encoded by the human THPO gene. This protein is involved in both megakaryocyte differentiation and platelet activation.

Display_Name

Thrombopoietin

FULL_SYN

Megakaryocyte Colony-Stimulating Factor

Megakaryocyte Stimulating Factor

C-MPL Ligand

Megakaryocyte Growth and Development Factor

Megakaryocyte Colony Stimulating Factor

Thrombopoietin

thrombopoietin

Prepro-Thrombopoietin

Myeloproliferative Leukemia Virus Oncogene Ligand

MGDF

ML

MPL Ligand

THPO

TPO

TSF

label

Thrombopoietin

Legacy Concept Name

Thrombopoietin

OMIM_Number

600044

Preferred_Name

Thrombopoietin

prefixIRI

Thesaurus:C20441

Semantic_Type

Amino Acid, Peptide, or Protein

Hormone

Swiss_Prot

P40225

UMLS_CUI

C0040052

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20586

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Delete Mapping To Ontology Source
http://www.orpha.net/ORDO/Orphanet_120091 ORDO LOOM
http://purl.obolibrary.org/obo/NCIT_C20441 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.374.410.240.750 RH-MESH LOOM
http://purl.jp/bio/4/id/200906005078800168 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.395.240.750 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.374.410.240.750 RH-MESH LOOM
http://id.nlm.nih.gov/mesh/D013926 MDM LOOM
http://purl.org/skeletome/bonedysplasia#P000169 BDO LOOM
http://www.bioassayontology.org/bao#BAO_0000771 BAO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12226 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP36417-1 LOINC LOOM
http://purl.obolibrary.org/obo/MESH_D013926 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0014771 OMIT LOOM
http://www.limics.org/hrdo/rdfns#gen_id_15617 HRDO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.374.410.240.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/F-D0830 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040052 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.395.720 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D013926 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/18617001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/OMIM/600044 OMIM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021553 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU019529 LOINC LOOM
http://www.semanticweb.org/demetrios/ontologies/2014/5/152 CYTO LOOM
http://purl.obolibrary.org/obo/PR_000016318 PR LOOM
http://purl.obolibrary.org/obo/PR_000016318 NIFSTD LOOM
https://go.drugbank.com/drugs/DB06534 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/019236 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013926 RH-MESH LOOM
http://www.ebi.ac.uk/efo/EFO_0003236 EFO LOOM