loading...| Preferred Name |
Aminolevulinic Acid Hydrochloride |
|
| Synonyms |
Levulan Kerastick Aminolevulinic Acid Hydrochloride 5-Amino-4-oxopentanoic Acid HCl 5-Amino-4-oxopentanoic Acid Hydrochloride AMINOLEVULINIC ACID HYDROCHLORIDE .delta.-Aminolevulinic acid hydrochloride Aminolevulinic Acid HCl Delta-Aminolevulinic Acid HCl aminolevulinic acid hydrochloride Delta-Aminolevulinic Acid Hydrochloride Alacare Ameluz Levulan |
|
| Definitions |
The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1849 |
|
| ALT_DEFINITION |
A drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid hydrochloride is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent. |
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| CAS_Registry |
5451-09-2 |
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| Chemical_Formula |
C5H9NO3.ClH |
|
| code |
C1849 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects. |
|
| Display_Name |
Aminolevulinic Acid Hydrochloride |
|
| FDA_UNII_Code |
V35KBM8JGR |
|
| FULL_SYN |
Levulan Kerastick Aminolevulinic Acid Hydrochloride 5-Amino-4-oxopentanoic Acid HCl 5-Amino-4-oxopentanoic Acid Hydrochloride AMINOLEVULINIC ACID HYDROCHLORIDE .delta.-Aminolevulinic acid hydrochloride Aminolevulinic Acid HCl Delta-Aminolevulinic Acid HCl aminolevulinic acid hydrochloride Delta-Aminolevulinic Acid Hydrochloride Alacare Ameluz Levulan |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Aminolevulinic Acid Hydrochloride |
|
| Legacy Concept Name |
Aminolevulinic_Acid_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
42648 |
|
| NSC Number |
18509 |
|
| PDQ_Closed_Trial_Search_ID |
42648 |
|
| PDQ_Open_Trial_Search_ID |
42648 |
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| Preferred_Name |
Aminolevulinic Acid Hydrochloride |
|
| prefixIRI |
Thesaurus:C1849 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0876231 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000042648 | PDQ | LOOM | |
| http://purl.bioontology.org/ontology/RXNORM/261715 | RXNORM | LOOM | |
| http://purl.bioontology.org/ontology/SNOMEDCT/784354008 | SNOMEDCT | LOOM | |
| http://id.nlm.nih.gov/mesh/D000622 | MDM | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C1849 | BERO | LOOM |