loading...| Preferred Name |
Peginterferon Alfa-2b |
|
| Synonyms |
PEG-IFN Alfa-2b PEG-interferon alfa-2b Polyethylene Glycol Interferon Alfa-2b Pegylated Interferon alfa-2b Pegylated Interferon Alpha-2b PEG Interferon Alpha-2b PEGINTERFERON ALFA-2B Peginterferon alfa-2b Polyethylene Glycol IFN-A2b PEG-Interferon Alfa-2b Peginterferon Alfa-2b PEG-IFN-a 2b PEG Intron PEG-Intron PegIntron SCH 54031 Sylatron |
|
| Definitions |
A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1845 |
|
| Accepted_Therapeutic_Use_For |
chronic hepatitis C; renal cell carcinoma |
|
| ALT_DEFINITION |
A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory. It is a type of biological response modifier. |
|
| CAS_Registry |
215647-85-1 |
|
| CHEBI_ID |
CHEBI:63615 |
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| Chemical_Formula |
C2H4NO2(C2H4O)n |
|
| code |
C1845 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04) |
|
| Display_Name |
Peginterferon Alfa-2b |
|
| FDA_UNII_Code |
G8RGG88B68 |
|
| FULL_SYN |
PEG-IFN Alfa-2b PEG-interferon alfa-2b Polyethylene Glycol Interferon Alfa-2b Pegylated Interferon alfa-2b Pegylated Interferon Alpha-2b PEG Interferon Alpha-2b PEGINTERFERON ALFA-2B Peginterferon alfa-2b Polyethylene Glycol IFN-A2b PEG-Interferon Alfa-2b Peginterferon Alfa-2b PEG-IFN-a 2b PEG Intron PEG-Intron PegIntron SCH 54031 Sylatron |
|
| Is_Value_For_GDC_Property | ||
| label |
Peginterferon Alfa-2b |
|
| Legacy Concept Name |
PEG-Interferon_Alfa-2B |
|
| Maps_To |
Peginterferon Alfa-2b |
|
| NCI_Drug_Dictionary_ID |
43407 |
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| NSC Number |
720033 |
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| PDQ_Closed_Trial_Search_ID |
43407 |
|
| PDQ_Open_Trial_Search_ID |
43407 |
|
| Preferred_Name |
Peginterferon Alfa-2b |
|
| prefixIRI |
Thesaurus:C1845 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
|
| UMLS_CUI |
C0796545 |
|
| subClassOf |