National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Levofloxacin Anhydrous
Synonyms

LEVOFLOXACIN ANHYDROUS

(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid

7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)-

Levofloxacin Anhydrous
Definitions

The anhydrous form of levofloxacin, a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170539
CAS_Registry

100986-85-4
Chemical_Formula

C18H20FN3O4
code

C170539
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The anhydrous form of levofloxacin, a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
FDA_UNII_Code

RIX4E89Y14
FULL_SYN

LEVOFLOXACIN ANHYDROUS

(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid

7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)-

Levofloxacin Anhydrous
label

Levofloxacin Anhydrous
NCI_META_CUI

CL1382974
Preferred_Name

Levofloxacin Anhydrous
prefixIRI

Thesaurus:C170539
Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C795
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