loading...| Preferred Name |
Nelarabine |
|
| Synonyms |
2-Amino, 6-Methoxypurine Arabinoside 2-Amino-6-methoxypurine arabinoside 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine Compound 506U78 506U78 Arranon GW506U78 NELARABINE Nelarabine nelarabine |
|
| Definitions |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1704 |
|
| Accepted_Therapeutic_Use_For |
T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma |
|
| ALT_DEFINITION |
A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
121032-29-9 |
|
| CHEBI_ID |
CHEBI:63612 |
|
| Chemical_Formula |
C11H15N5O5 |
|
| code |
C1704 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04) |
|
| Display_Name |
Nelarabine |
|
| FDA_UNII_Code |
60158CV180 |
|
| FULL_SYN |
2-Amino, 6-Methoxypurine Arabinoside 2-Amino-6-methoxypurine arabinoside 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine Compound 506U78 506U78 Arranon GW506U78 NELARABINE Nelarabine nelarabine |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Nelarabine |
|
| Legacy Concept Name |
Nelarabine |
|
| Maps_To |
Nelarabine |
|
| NCI_Drug_Dictionary_ID |
43260 |
|
| NSC Number |
686673 |
|
| PDQ_Closed_Trial_Search_ID |
43260 |
|
| PDQ_Open_Trial_Search_ID |
43260 |
|
| Preferred_Name |
Nelarabine |
|
| prefixIRI |
Thesaurus:C1704 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0907349 |
|
| subClassOf |