National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
loading...
Preferred Name

Ganciclovir Sodium
Synonyms

Ganciclovir sodium

RS-21592 Sodium

Cytovene-IV

9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, Monosodium Salt

Ganciclovir Sodium

DHPG sodium

GANCICLOVIR SODIUM

DHPG Sodium

BIOLF-62

BW-759

BW-759U

Cymevene

Cytovene

Denosine

GCV Sodium

GCV sodium
Definitions

The sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1588
CAS_Registry

107910-75-8
Chemical_Formula

C9H12N5O4.Na
code

C1588
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.
FDA_UNII_Code

02L083W284
FULL_SYN

Ganciclovir sodium

RS-21592 Sodium

Cytovene-IV

9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, Monosodium Salt

Ganciclovir Sodium

DHPG sodium

GANCICLOVIR SODIUM

DHPG Sodium

BIOLF-62

BW-759

BW-759U

Cymevene

Cytovene

Denosine

GCV Sodium

GCV sodium
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C517
label

Ganciclovir Sodium
Legacy Concept Name

Ganciclovir_Sodium
Preferred_Name

Ganciclovir Sodium
prefixIRI

Thesaurus:C1588
Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI

C0282399
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29575
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display