loading...| Preferred Name |
Secukinumab |
|
| Synonyms |
Secukinumab SECUKINUMAB AIN457 Cosentyx |
|
| Definitions |
A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152315 |
|
| CAS_Registry |
1229022-83-6 |
|
| code |
C152315 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA |
|
| DEFINITION |
A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response. |
|
| FDA_UNII_Code |
DLG4EML025 |
|
| FULL_SYN |
Secukinumab SECUKINUMAB AIN457 Cosentyx |
|
| label |
Secukinumab |
|
| NCI_Drug_Dictionary_ID |
803239 |
|
| NCI_META_CUI |
CL553647 |
|
| PDQ_Closed_Trial_Search_ID |
803239 |
|
| PDQ_Open_Trial_Search_ID |
803239 |
|
| Preferred_Name |
Secukinumab |
|
| prefixIRI |
Thesaurus:C152315 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| subClassOf |