loading...| Preferred Name |
Lamivudine |
|
| Synonyms |
2',3'-Dideoxy-3'-thiacytidine 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone (-)-BCH-189 3'-Thia-2',3'-dideoxycytidine 3TC Epivir GR109714X LAM LAMIVUDINE Lamivudine lamivudine |
|
| Definitions |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1471 |
|
| Accepted_Therapeutic_Use_For |
Chronic hepatitis B; HIV infection |
|
| ALT_DEFINITION |
A drug used to treat infection caused by viruses. |
|
| CAS_Registry |
134678-17-4 |
|
| CHEBI_ID |
CHEBI:63577 |
|
| Chemical_Formula |
C8H11N3O3S |
|
| code |
C1471 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04) |
|
| Display_Name |
Lamivudine |
|
| FDA_UNII_Code |
2T8Q726O95 |
|
| FULL_SYN |
2',3'-Dideoxy-3'-thiacytidine 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone (-)-BCH-189 3'-Thia-2',3'-dideoxycytidine 3TC Epivir GR109714X LAM LAMIVUDINE Lamivudine lamivudine |
|
| label |
Lamivudine |
|
| Legacy Concept Name |
Lamivudine |
|
| NCI_Drug_Dictionary_ID |
42593 |
|
| PDQ_Closed_Trial_Search_ID |
42593 |
|
| PDQ_Open_Trial_Search_ID |
42593 |
|
| Preferred_Name |
Lamivudine |
|
| prefixIRI |
Thesaurus:C1471 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0209738 |
|
| subClassOf |