loading...| Preferred Name |
Calcineurin Inhibitor |
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| Synonyms |
Calcineurin Inhibitor CNI Inhibitor |
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| Definitions |
Any agent that inhibits calcineurin (protein phosphatase 3; PPP3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated T-cells, cytoplasmic (NFATc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (IL-2). This prevents IL-2-mediated proliferation and activation of T-cells, and T-lymphocyte-mediated immune responses. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C146638 |
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| code |
C146638 |
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| Concept_In_Subset | ||
| Contributing_Source |
CTRP |
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| DEFINITION |
Any agent that inhibits calcineurin (protein phosphatase 3; PPP3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated T-cells, cytoplasmic (NFATc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (IL-2). This prevents IL-2-mediated proliferation and activation of T-cells, and T-lymphocyte-mediated immune responses. |
|
| Display_Name |
Calcineurin Inhibitor |
|
| FULL_SYN |
Calcineurin Inhibitor CNI Inhibitor |
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| Has_Target | ||
| label |
Calcineurin Inhibitor |
|
| Preferred_Name |
Calcineurin Inhibitor |
|
| prefixIRI |
Thesaurus:C146638 |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C1562036 |
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| subClassOf |