loading...| Preferred Name |
Granisetron Hydrochloride |
|
| Synonyms |
granisetron hydrochloride Endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide Hydrochloride Granisetron Hydrochloride GRANISETRON HYDROCHLORIDE Kytril |
|
| Definitions |
The hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1353 |
|
| Accepted_Therapeutic_Use_For |
Chemotherapy- and postoperative-induced nausea and vomiting, treatment and prophylaxis |
|
| ALT_DEFINITION |
A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic. |
|
| CAS_Registry |
107007-99-8 |
|
| Chemical_Formula |
C18H24N4O.HCl |
|
| code |
C1353 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. |
|
| Display_Name |
Granisetron Hydrochloride |
|
| FDA_UNII_Code |
318F6L70J8 |
|
| FULL_SYN |
granisetron hydrochloride Endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide Hydrochloride Granisetron Hydrochloride GRANISETRON HYDROCHLORIDE Kytril |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| label |
Granisetron Hydrochloride |
|
| Legacy Concept Name |
Granisetron |
|
| NCI_Drug_Dictionary_ID |
42236 |
|
| NSC Number |
672814 |
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| PDQ_Closed_Trial_Search_ID |
42236 |
|
| PDQ_Open_Trial_Search_ID |
42236 |
|
| Preferred_Name |
Granisetron Hydrochloride |
|
| prefixIRI |
Thesaurus:C1353 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0543476 |
|
| subClassOf |