loading...| Preferred Name |
Pamidronate Disodium |
|
| Synonyms |
Pamidronate Disodium PAMIDRONATE DISODIUM Aminomux Aredia GCP-23339A |
|
| Definitions |
The disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1345 |
|
| Accepted_Therapeutic_Use_For |
Hypercalcemia of malignancy; Osteolytic bone lesions of multiple myeloma; Osteolytic bone metastases of breast cancer; Pagets disease |
|
| CAS_Registry |
109552-15-0 |
|
| Chemical_Formula |
C3H9NO7P2.2Na.5H2O |
|
| code |
C1345 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation. |
|
| Display_Name |
Pamidronate Disodium |
|
| FDA_UNII_Code |
8742T8ZQZA |
|
| FULL_SYN |
Pamidronate Disodium PAMIDRONATE DISODIUM Aminomux Aredia GCP-23339A |
|
| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Pamidronate Disodium |
|
| Legacy Concept Name |
Pamidronate_Disodium |
|
| Maps_To |
Pamidronate Disodium |
|
| NCI_Drug_Dictionary_ID |
39149 |
|
| NSC Number |
720699 |
|
| PDQ_Closed_Trial_Search_ID |
39149 |
|
| PDQ_Open_Trial_Search_ID |
39149 |
|
| Preferred_Name |
Pamidronate Disodium |
|
| prefixIRI |
Thesaurus:C1345 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0356588 |
|
| subClassOf |