loading...| Preferred Name |
Valrubicin |
|
| Synonyms |
N-Trifluoroacetyladriamycin-14-valerate AD 32 AD-32 VALRUBICIN Valrubicin Valstar Valtaxin valrubicin |
|
| Definitions |
A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1340 |
|
| ALT_DEFINITION |
A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic. |
|
| CAS_Registry |
56124-62-0 |
|
| Chemical_Formula |
C34H36F3NO13 |
|
| code |
C1340 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations. |
|
| Display_Name |
Valrubicin |
|
| FDA_UNII_Code |
2C6NUM6878 |
|
| FULL_SYN |
N-Trifluoroacetyladriamycin-14-valerate AD 32 AD-32 VALRUBICIN Valrubicin Valstar Valtaxin valrubicin |
|
| Is_Value_For_GDC_Property | ||
| label |
Valrubicin |
|
| Legacy Concept Name |
Valrubicin |
|
| Maps_To |
Valrubicin |
|
| NCI_Drug_Dictionary_ID |
39135 |
|
| NSC Number |
246131 |
|
| PDQ_Closed_Trial_Search_ID |
39135 |
|
| PDQ_Open_Trial_Search_ID |
39135 |
|
| Preferred_Name |
Valrubicin |
|
| prefixIRI |
Thesaurus:C1340 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0068314 |
|
| subClassOf |