loading...| Preferred Name |
Cladribine |
|
| Synonyms |
2-Chloro-2-Deoxyadenosine 2-Chlorodeoxyadenosine 2-CdA 2CDA CLADRIBINE CdA Cladribina Cladribine Leustat Leustatin Leustatine RWJ-26251 cladribine |
|
| Definitions |
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1336 |
|
| Accepted_Therapeutic_Use_For |
Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
4291-63-8 |
|
| CHEBI_ID |
CHEBI:567361 |
|
| Chemical_Formula |
C10H12ClN5O3 |
|
| code |
C1336 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04) |
|
| DesignNote | ||
| Display_Name |
Cladribine |
|
| FDA_UNII_Code |
47M74X9YT5 |
|
| FULL_SYN |
2-Chloro-2-Deoxyadenosine 2-Chlorodeoxyadenosine 2-CdA 2CDA CLADRIBINE CdA Cladribina Cladribine Leustat Leustatin Leustatine RWJ-26251 cladribine |
|
| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Cladribine |
|
| Legacy Concept Name |
Cladribine |
|
| Maps_To |
Cladribine |
|
| NCI_Drug_Dictionary_ID |
41184 |
|
| NSC Number |
105014 105014-F |
|
| PDQ_Closed_Trial_Search_ID |
41184 |
|
| PDQ_Open_Trial_Search_ID |
41184 |
|
| Preferred_Name |
Cladribine |
|
| prefixIRI |
Thesaurus:C1336 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0092801 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C798 |