loading...| Preferred Name |
Fluoroquinolone Antibiotic |
|
| Synonyms |
Fluoroquinolone Fluoroquinolones Fluoroquinolone Antibiotic |
|
| Definitions |
Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126712 |
|
| code |
C126712 |
|
| Concept_In_Subset | ||
| Contributing_Source |
CTRP |
|
| DEFINITION |
Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation. |
|
| Display_Name |
Fluoroquinolone Antibiotic |
|
| FULL_SYN |
Fluoroquinolone Fluoroquinolones Fluoroquinolone Antibiotic |
|
| label |
Fluoroquinolone Antibiotic |
|
| Preferred_Name |
Fluoroquinolone Antibiotic |
|
| prefixIRI |
Thesaurus:C126712 |
|
| Semantic_Type |
Chemical Viewed Functionally |
|
| UMLS_CUI |
C0949665 |
|
| subClassOf |