loading...| Preferred Name |
Sodium Thiosulfate |
|
| Synonyms |
Thiosulfate, Sodium, Pentahydrate Disodium thiosulfate Sodium Thiosulphate Sodium Thiosulfate SODIUM THIOSULFATE Sodium Thiosulfate Pentahydrate Cyanide Antidote Package Thiosulfuric Acid Disodium Salt Disodium Thiosulfate Sodium thiosulfate Sodium Hyposulfate Thiosulfuric acid disodium salt sodium thiosulfate S-Hydril Sodothiol |
|
| Definitions |
A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1230 |
|
| Accepted_Therapeutic_Use_For |
Cisplatin-induced nephrotoxicity; Nitrogen mustard-induced skin toxicity, neutralizer; Poisoning, arsenic and cyanide |
|
| ALT_DEFINITION |
A substance that is used in medicine as an antidote to cyanide poisoning and to decrease side effects of the anticancer drug cisplatin. |
|
| CAS_Registry |
10102-17-7 |
|
| CHEBI_ID |
CHEBI:32150 |
|
| Chemical_Formula |
2Na.O3S2.5H2O |
|
| code |
C1230 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177404 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| DEFINITION |
A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04) |
|
| Display_Name |
Sodium Thiosulfate |
|
| FDA_UNII_Code |
HX1032V43M |
|
| FULL_SYN |
Thiosulfate, Sodium, Pentahydrate Disodium thiosulfate Sodium Thiosulphate Sodium Thiosulfate SODIUM THIOSULFATE Sodium Thiosulfate Pentahydrate Cyanide Antidote Package Thiosulfuric Acid Disodium Salt Disodium Thiosulfate Sodium thiosulfate Sodium Hyposulfate Thiosulfuric acid disodium salt sodium thiosulfate S-Hydril Sodothiol |
|
| Is_PCDC_GCT_Authorized_Value_For_Variable | ||
| label |
Sodium Thiosulfate |
|
| Legacy Concept Name |
Sodium_Thiosulfate |
|
| NCI_Drug_Dictionary_ID |
39602 |
|
| NSC Number |
45624 |
|
| PDQ_Closed_Trial_Search_ID |
39602 |
|
| PDQ_Open_Trial_Search_ID |
39602 |
|
| Preferred_Name |
Sodium Thiosulfate |
|
| prefixIRI |
Thesaurus:C1230 |
|
| Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
|
| UMLS_CUI |
C0074774 |
|
| subClassOf |