loading...| Preferred Name |
Olsalazine |
|
| Synonyms |
3,3'-Dicarboxy-4,4'-dihydroxyazobenzene C.I. Mordant Yellow 5 Azodisalicylate 3,3'-Azobis[6-hydroxybenzoic Acid] OLSALAZINE Olsalazine |
|
| Definitions |
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1176 |
|
| Accepted_Therapeutic_Use_For |
Ulcerative colitis |
|
| CAS_Registry |
15722-48-2 |
|
| CHEBI_ID |
CHEBI:7770 |
|
| Chemical_Formula |
C14H10N2O6 |
|
| code |
C1176 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals. |
|
| FDA_UNII_Code |
ULS5I8J03O |
|
| FULL_SYN |
3,3'-Dicarboxy-4,4'-dihydroxyazobenzene C.I. Mordant Yellow 5 Azodisalicylate 3,3'-Azobis[6-hydroxybenzoic Acid] OLSALAZINE Olsalazine |
|
| Has_Salt_Form | ||
| label |
Olsalazine |
|
| Legacy Concept Name |
Olsalazine |
|
| NCI_Drug_Dictionary_ID |
41828 |
|
| PDQ_Closed_Trial_Search_ID |
41828 |
|
| PDQ_Open_Trial_Search_ID |
41828 |
|
| Preferred_Name |
Olsalazine |
|
| prefixIRI |
Thesaurus:C1176 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0069454 |
|
| subClassOf |