loading...| Preferred Name |
Fenretinide |
|
| Synonyms |
FENRETINIDE all-trans-N-(4-Hydroxyphenyl)retinamide fenretinide 4-Hydroxyphenylretinamide Fenretinimide Fenretinide 4-(all-trans-retino-yl)aminophenol all-trans-4'-hydroxyretinanilide all-trans-N-4'-hydroxyretinanilide N-(4-hydroxyphenyl)retinamide All-trans-4'-Hydroxyretinanilide 4-HPR HPR-4 McN-R-1967 |
|
| Definitions |
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1098 |
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| ALT_DEFINITION |
A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A. |
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| CAS_Registry |
65646-68-6 |
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| CHEBI_ID |
CHEBI:42588 |
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| Chemical_Formula |
C26H33NO2 |
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| code |
C1098 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
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| DEFINITION |
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04) |
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| Display_Name |
Fenretinide |
|
| FDA_UNII_Code |
187EJ7QEXL |
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| FULL_SYN |
FENRETINIDE all-trans-N-(4-Hydroxyphenyl)retinamide fenretinide 4-Hydroxyphenylretinamide Fenretinimide Fenretinide 4-(all-trans-retino-yl)aminophenol all-trans-4'-hydroxyretinanilide all-trans-N-4'-hydroxyretinanilide N-(4-hydroxyphenyl)retinamide All-trans-4'-Hydroxyretinanilide 4-HPR HPR-4 McN-R-1967 |
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Fenretinide |
|
| Legacy Concept Name |
Fenretinide |
|
| Maps_To |
Fenretinide |
|
| NCI_Drug_Dictionary_ID |
39582 |
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| NSC Number |
374551 |
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| PDQ_Closed_Trial_Search_ID |
39582 |
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| PDQ_Open_Trial_Search_ID |
39582 |
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| Preferred_Name |
Fenretinide |
|
| prefixIRI |
Thesaurus:C1098 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0060197 |
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| subClassOf |